The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could end in a rise in methadone plasma concentrations, which could lead to most likely deadly respiratory melancholy. Also, discontinuation of concomitantly applied cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers could also end in a rise in methadone pl